Figure 1.

This figure illustrates significant differences in cannabis users relative to non-users in both ADC and FA. Coronal, sagittal and axial views (moving from left to right, respectively) illustrate that the apparent diffusion coefficient (ADC) for adolescent cannabis users (N = 10) was significantly (p < 0.01, cluster size >200 mm³) lower relative to non-cannabis users (N = 10) in left middle frontal gyrus (a): Talairach coordinates -41 [L],3 [A],36 [S], and posterior to the right posterior cingulate (b): 2 [R],-54 [P],4 [S] (shown in orange superimposed on the average registered MPRAGE images from all 20 subjects), and that the fractional anisotropy (FA) was significantly higher (shown in blue) in cannabis users in the left anterior cingulate (c): -16 [L],32 [A],11 [S], right medial frontal gyrus (d): 3 [R],46 [A],18 [S], left precentral gyrus (e): -32 [L],1 [A],33 [S], right inferior parietal (f): 50 [R],-38 [P],39 [S], right cingulate gyrus (g): 10 [R],-3 [P],35 [S], and left superior frontal gyrus (h): -20 [L],21 [A],45 [S].